Name: Proton Pump Inhibitors Aciphex Nexium Prevacid Prilosec Protonix
Generic: Raberprazole Esomeprazole Lansoprazole Omeprazole Pantoprazole
Manufacturer: Eisai (Aciphex/Raberprazole) AstraZeneca (Nexium/Esomeprazole and Prilosec/Omeprazole) TAP Pharmaceuticals Inc. (Pevacid/Lansoprazole) Wyeth-Ayerst (Protonix/Pantoprazole)
Date approved: Aciphex was approved in 1999 Nexium was approved in 2001 Prevacid was approved in 2000 Prilosec was approved in 2003 Protonix was approved by the FDA in 2000
Status: On the market
Approved uses: Gastroesophageal Reflux Disease (GERD)
Off-Label uses: Ulcers, Zollinger-Ellison Syndrome, H. Pylori infection of the stomach, Laryngitis
• Increased risk of hip fracture and other fractures
• abdominal pain
• muscle pain
• abnormal heartbeat
• leg cramps
Common Misspellings: PPIs, proton pump, proton pump inhibitors, proton pump inhibitor, proton pumps, PPI, PPI’s
Proton Pump Inhibitors
Proton Pump Inhibitors (PPIs) are a group of drugs that work to reduce gastric acid production. The stomach contains a pump that produces gastric acid; PPIs bind this pump and prevent acid from being pumped into the stomach. Medications such as Prilosec, Prevacid, Nexium and Aciphex are prescribed to patients with gastroesophageal reflux disease (GERD), dyspepsia, ulcers, Zollinger-Ellison Syndrome and sometimes stomach infections.
Although most side effects of Proton Pump inhibitors are minor, PPIs have recently been linked to an increased risk of bone fractures. In particular, those who have been on a PPI for 5 or more consecutive years are at a greater risk of hip fracture. Those who have been on a PPI for 7 plus years are at greater risk of fractures in general and osteoporosis.
Details of Proton Pump Inhibitor Drugs’ Use and Side Effects
A group of drugs known as Proton Pump Inhibitors (PPIs) were recently discovered to be linked with severe bone fractures and bone density loss among patients. The drugs are used to control and reduce gastric acid production and inhibit acid secretion.
In August 2008, the Canadian Medical Association Journal found that PPIs may reduce calcium absorption, thus causing early onset osteoporosis and bone fracture among patients, especially those taking PPIs for five to seven years or longer. The study echoed results of a similar study published in a December 2006 issue of the Journal of the American Medical Association, which found that long-term, high-dose consumption of PPIs contributed to hip fractures among patients.
According to an American Medical News article from September 2008, the National Osteoporosis Foundation reports that approximately 44 million Americans, which accounts for 55 percent of the 50-years-of-age or older population suffer from osteoporosis and bone fractures.
What are PPIs Used For?
Proton Pump Inhibitors (PPIs) were introduced to help patients suffering from an array of conditions find relief with a reduction of gastric acid production. PPIs can be used for treatment of the following:
• Zollinger-Ellison syndrome
• Gastroesophageal Reflux Disease (GERD)
• Stress gastritis
• Barrett’s esophagus
• Peptic ulcer disease (PUD)
• Laryngopharyngeal Reflux Disease
• Conditions causing hypersecretion of acid
The PPIs account for a nearly $13 billion dollar a year industry, considered one of the most popular drugs available coming in only second to cholesterol drugs, according to an article from The Wall Street Journal.
Proton Pump Inhibitor Side Effects
While two medical studies have reported significant dangers associated with consuming PPIs, their have been no proton pump inhibitor recalls and Sameer Dev Saini, MD, the lead author of the Journal of American Medical Associations believes that the evidence is not concrete enough for patients to receive different prescription habits, according to the American Medical News article. However, physicians are recommending stronger warnings as well as an increased consumption of calcium and vitamin D intake. Common PPI side effects include:
• Mild dizziness
Patients who are currently taking PPIs and are suffering from the following side effects may want to consider consulting a physician to ensure the PPI is not causing unseen damages:
• brittle bones
• bone fractures
• breaking bones
Overcoming PPI Risks
PPIs are most commonly known for treating or reducing heartburn, however, there are several other treatments that can be considered to reduce heartburn as well as consumption of PPIs, which have severe risks associated with them. Some additional treatment options include:
• Change in diet, including cutting back on high-fat meals, alcohol, caffeine and soda
• Consuming antacids, such as Tums, Rolaids, Mylanta, to neutralize acid production
• Consumption of H-2 Blockers (Pepcid, Zantac and Tagament), which block acid production
• Pro-motility drugs, such as Propulsid, that hasten gastric emptying
• Antireflux surgery
Several of the more common PPIs brand names include:
• Aciphex (rabeprazole)
• Prilosec (omepraazole)
• Nexium (esomeprazole)
• Prevacid (lansoprazole)
• Protonix (pantoprazole)
Individuals suffering from any of the above conditions who have been taking PPIs for several years should consult a medical professional immediately, as the patient may be at extreme risks for developing early onset osteoporosis. Additionally, while it may seem frightening at first to contact a legal professional as well, a legal consultation is often free of charge and can provide insight into how to receive monetary compensation for the severity of damages done to a patient who now suffers from PPI-induced bone fractures.
Proton Pump Inhibitors May Lead to Osteoporosis
Heartburn and acid reflux disease are among some of the most common ailments of US citizens and patients across the world. Gastroesophageal reflux disease is treated in patients by the millions every year in in the U.S. Therefore, it is not surprising that Proton Pump Inhibitors (PPIs) – a class of stomach acid reduction drugs – represent a $14 billion dollar industry.